Only the S-Enantiomer of Naproxen Inhibits the COX-1 and COX-2

question 50

Multiple Choice

Only the S-enantiomer of naproxen inhibits the COX-1 and COX-2 enzymes, the R-enantiomer is a strong liver toxin. Therefore, only enantiomerically pure naproxen is sold in US pharmacies. Unfortunately, the classic synthesis leads to a racemic mixture. Which base do you use to separate the two enantiomers by recrystallization?

• A) I
• B) II
• C) III
• D) IV

---

Definitions:

Toxic Shock Syndrome

A rare, life-threatening complication of certain bacterial infections, often associated with tampon use in menstruating women.

Intrauterine Device (IUD)

A small, T-shaped device inserted into the uterus by a healthcare provider as a method of long-term contraception.

Uterus

An organ in the female reproductive system where embryonic and fetal development occurs.

Diaphragm Users

Individuals who use a diaphragm, a form of birth control that is placed inside the vagina to cover the cervix and prevent pregnancy.