Use the Figure Below and Find the INCORRECT Statement Regarding

question 38

Multiple Choice

Use the figure below and find the INCORRECT statement regarding the development process for the antituberculosis compound SQ109.

• A) The question mark (?) indicates to the general formula for 62,238 compounds made in a combinatorial library of ethambutol derivatives.
• B) The yellow highlighted portion of the molecules correspond to the ethambutol diamine core.
• C) All 63,238 diamine molecules in the combinatorial library were tested in tissue culture, activity in infected macrophages and in live animals.
• D) Out of 69 compounds showing the best activity against Mycobacterium tuberculosis, SQ109 had the greatest efficacy and fewer side effects.
• E) Out of 63,238 diamine molecules in the combinatorial library, 2,796 showed activity against Mycobacterium tuberculosis in vitro.

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