Some Patients Suffering from Bare Lymphocyte Syndrome (BLS), a Rare

question 29

Essay

Some patients suffering from bare lymphocyte syndrome (BLS), a rare immunodeficiency, have a genetic mutation in their TAP1/TAP2 genes causing the production of a defective TAP transporter. Describe what effect this has on antigen processing and in what cells.

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Definitions:

High-pitched Sounds

Sounds that have a high frequency, typically perceived by the ear as having a higher note or sharper tone.

Auscultation

The act of listening to the sounds made by internal organs of the body, usually with a stethoscope, for medical diagnosis.

Tender Areas

Specific regions on the body that are sensitive or painful to touch, often indicating inflammation or underlying medical conditions.