Briefly Explain Why a Drug Candidate That Has a Partition

question 27

Essay

Briefly explain why a drug candidate that has a partition coefficient (log P) greater than 5 is not a good candidate for oral bioavailability.

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Definitions:

Polynomial

A mathematical expression consisting of variables and coefficients, that involves only the operations of addition, subtraction, multiplication, and non-negative integer exponents.

Factor

A number that divides another number exactly, without leaving a remainder, or the process of breaking down expressions into simpler components that can be multiplied together.

Extraneous Solutions

Solutions that are derived during the process of solving an equation but do not satisfy the original equation.

Equation

A mathematical statement asserting the equality of two expressions, typically involving variables, and solved to find the values of those variables.