A New Medication Is Developed That Targets and Binds to the Lipid

question 70

Multiple Choice

A new medication is developed that targets and binds to the lipid A portion of LPS in Gram-negative bacterial cells. This drug shows a high degree of binding and activity against purified lipid A in an experiment carried out in test tubes. Based on this information,

• A) we should fast-track this drug and get it out to physicians immediately to help prevent Gram-negative toxic/septic shock in humans.
• B) we should do some animal testing with intact Gram-negative cells and the medication before we jump to any conclusions.
• C) we should next proceed by repeating the experiment in test tubes using intact Gram-negative cells to see if the drug binds with the same strength.
• D) we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. 
• E) we should assume that the medication will be effective against all bacteria, including Mycoplasmas, and that it is ready for use in humans.

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