Why Would Co-Administration of a Bacteriostatic Drug Interfere with the Effects

question 56

Multiple Choice

Why would co-administration of a bacteriostatic drug interfere with the effects of penicillin?

• A) Since most bacteriostatic drugs are produced from bacteria but penicillin is produced from mold, the two drugs are incompatible with each other.
• B) A bacteriostatic drug interferes with the ability of a bacterial cell to take in compounds from the outside environment. Penicillin must be taken in by the cell in order to have its effect, so this would directly inhibit it.
• C) The bacteriostatic drugs would bind directly to the penicillin, preventing both its uptake by the cell and its ability to perform its duty within the bacterial cell.
• D) Penicillin interferes with cell wall production so it only works when the cells are actively replicating and MAKING new peptidoglycan. A bacteriostatic drug works by shutting down replication, holding the cells "static." This would interfere with the mode of action required by the penicillin.
• E) Nothing interferes with the effects of penicillin. It is the most effective medication that we have, so is never used with the addition of a second drug when treating a person.

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