Which of the Following Possibly Explains the Development of Dengue

question 22

Multiple Choice

Which of the following possibly explains the development of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) ?

• A) Previously formed antibodies to one serotype of dengue virus bind to the second serotype and rather than neutralizing it, facilitate its entry into cells that express Fc receptors. This leads to increased numbers of infected cells and a high viral load.
• B) Previously formed antibodies to one serotype of dengue virus suppress the immune response to infection with other serotypes; this allows the second infection to become much more severe than the first infection.
• C) Infection with one serotype of dengue virus results in the formation of clots in small blood vessels throughout the body; viruses from a second infection enter these clots and multiply uninhibited within them, resulting in serious disease.
• D) Antibodies generated in response to one serotype of dengue virus cross react with a second serotype of the virus. This leads to the formation of immune complexes that lodge in the brains of infected people, causing serous illness.
• E) Dengue viruses are DNA viruses that can integrate into the chromosome of the host cell. If a cell is already infected with one serotype of the virus, infection with a second serotype will lead to the death of that cell.

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