Why Is It Thought That a Val66Met Polymorphism Existing on the Gene

question 31

Multiple Choice

Why is it thought that a Val66Met polymorphism existing on the gene for BDNF may lead to decreased treatment responses to antidepressants (Horstmann & Binder, 2009; Shimizu, Hashimoto, & Iyo, 2004) ?

• A) This may accelerate dopamine metabolism.
• B) This may increase serotonin transporters levels.
• C) This may enhance the expression of GSK-3.
• D) This may lead to reduced levels of the TrkB receptors.