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Glutamate's NMDA-Receptor Is Activated in Response to the Binding of Glutamate

question 49

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Glutamate's NMDA-receptor is activated in response to the binding of glutamate. However, the NMDA receptor also requires D-serine to be tightly bound on a distant receptor site. Without bound D-serine, glutamate cannot activate NMDA receptors. The site to which D-serine binds is referred to as a(n) ____ site.


Definitions:

Functional Connectivity

Refers to the statistical association between different brain regions, indicating how various parts of the brain communicate and function together.

Major Depressive Disorder

A mental disorder characterized by a persistent and pervasive low mood accompanied by low self-esteem and loss of interest or pleasure in normally enjoyable activities.

Emotion-related Regions

Areas of the brain involved in the processing, regulation, and expression of emotions.

Socially Withdrawn

Refers to individuals who prefer to be alone and avoid social interactions.

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