In Addition to Loss of Heterozygosity, the Second Hit in Sporadic

question 9

Multiple Choice

In addition to loss of heterozygosity, the second hit in sporadic breast cancers with breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2) mutations is often which of the following?

• A) Methylation of the BRCA1 or BRCA2 promoter
• B) Acetylation of the BRCA2 or BRCA2 promoter
• C) Deletion of the tumor-associated transplantation antigen (TATA) box in BRCA1 or BRCA2
• D) Deletion of a BRCA1 or BRCA2 enhancer
• E) Nonsense mutation in BRCA2 or BRCA2

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Definitions:

Item Response Theory (IRT)

A theory and method used in education and psychology to model the relationship between individuals' skills or traits and their performance on test items.

Empirical Method

A scientific approach that relies on observation and experiment rather than theory or pure logic.

Fundamental Personality Traits

Core traits believed to constitute the foundation of human personality, often related to the Big Five personality dimensions.

Rational Method

An approach based on reason and logic in decision-making or problem-solving, often involving systematic steps.