How Does Curcumin Treatment Lead to a Normalization of Chloride

question 17

Multiple Choice

How does curcumin treatment lead to a normalization of chloride transport in mice with the cystic fibrosis transmembrane conductance regulator (CFTR) DF508 mutation?

• A) It causes skipping of the mutated codon
• B) It is a cofactor for the CFTR protein
• C) It prevents retention and degradation of CFTR in the endoplasmic reticulum
• D) It prevents transport of the mutant CFTR to the lysosome
• E) It inhibits the proteasome

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Definitions:

Heterozygous Individuals

Organisms having two different alleles for a specific gene, one inherited from each parent.

Positive Assortative Mating

A mating pattern where individuals with similar phenotypes or genotypes are more likely to mate with each other than by chance.

Homozygosity

Homozygosity is a genetic condition in which an individual has two identical alleles for a particular gene or genes.

Allele Frequencies

A measure of how common a particular genetic variant (allele) is within a population's gene pool.