What Modification Lead to Increased Success of Enzyme Replacement Therapy

question 15

Multiple Choice

What modification lead to increased success of enzyme replacement therapy for Gaucher disease?

• A) Removal of phosphate groups to improve targeting to central nervous system
• B) Removal of terminal sugars to increase uptake by macrophages
• C) Removal of phosphate groups to increase protein half-life
• D) Addition of polyethylene glycol to increase protein half-life
• E) Addition of terminal sugars to increase uptake by macrophages

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Definitions:

Procedural Justice

Refers to the fairness of the processes that lead to outcomes.

Achievement Motivation

A person's drive to pursue and achieve goals, often involving competition or overcoming challenges.

High Achiever

An individual who consistently exceeds standard expectations and goals through hard work and talent.

Equity Model

A theoretical framework suggesting that fairness in the distribution of resources and rewards within social relationships and organizations is essential for satisfaction and motivation.