Which Type of Mutation Is Likely to Be Associated with a Milder

question 33

Multiple Choice

Which type of mutation is likely to be associated with a milder osteogenesis imperfecta phenotype?

• A) Missense mutation for glycine in pro\(\alpha\)₁(1) chain
• B) Missense mutation for glycine in pro\(\alpha\)₁ (1)) chain
• C) Missense mutation in either chain disrupting rate of \(\alpha\) helix formation
• D) Mutation affecting posttranslational modification of collagen
• E) Null mutation for pro\(\alpha\)₁(1) chain

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