Why Is It Believed That Transitions Are Overrepresented Among the Disease-Causing

question 18

Multiple Choice

Why is it believed that transitions are overrepresented among the disease-causing mutations?

• A) Increased susceptibility of guanines to mutagens
• B) Weaker hydrogen bonding between A-T pairs
• C) Spontaneous deamination of 5-methylcytosines
• D) Overrepresentation of cytosine phosphate guanine (CpG) in the genome
• E) DNA repair mechanisms work less efficiently on these changes

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