Two Children in the Same Family Have Recurrent, Chronic Bruising

question 25

Multiple Choice

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work. Which type of disorder is most likely?
-Which of the following would be appropriate initial testing for the siblings in Question above?

• A)fibrinogen, D-dimer, and platelet aggregation studies
• B)factor VIII assay, liver function tests, and vitamin K level
• C)von Willebrand factor (VWF) antigen, Bethesda titer, and reptilase time
• D)prothrombin time (PT), partial thromboplastin time (PTT), and platelet count

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Definitions:

Electrical Synapses

A type of synapse in which electrical currents flow directly from one cell to another via gap junctions, facilitating rapid communication.

Presynaptic Terminal

The end part of a nerve cell (neuron) that releases neurotransmitters to send a signal across the synapse to another neuron.

Acetylcholine

A neurotransmitter involved in many functions including muscle activation, heart rate, and the processing of memory and cognition.

Synaptic Cleft

The microscopic gap between neurons across which neurotransmitters are released, facilitating communication between cells.