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Wes, a neighbour of Stan, wished to borrow a sum of money from a local bank. Stan was quite wealthy, but elderly, with very poor eyesight. He frequently requested Wes to read his newspaper to him when Wes would drop by for a visit, because reading bothered his eyes. One evening, Wes placed a paper before Stan, and explained to him that he wished to borrow a sum of money but required a letter of reference before the bank would make the loan. He requested Stan to sign the paper to satisfy this requirement. Stan trusted his friend Wes and signed the paper at his request without reading it. Unknown to Stan, the paper was a guarantee of Wes's indebtedness, and not a letter of reference. Wes later defaulted on his debt. Wes required Stan's signature on the paper because the Statute of Frauds requires a guarantee to be in writing, and signed by the guarantor to be enforceable.
Cross-tolerance
A phenomenon where tolerance to the effects of a certain drug results in a reduced response to another drug, often because the two drugs affect similar brain pathways.
Potentiation
The increase in strength or effectiveness of a drug, action, or biological response when combined with another substance or condition.
Double Bind
A situation in which a person receives conflicting messages, making it impossible to appropriately respond or resolve the situation.
Narcotic Antagonist
A medication that blocks or reverses the effects of opioids.
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