Factor the perfect square trinomial. 
Definitions:
Master Biological Clock
A mechanism within the brain, specifically the suprachiasmatic nucleus of the hypothalamus, that regulates the circadian rhythms of the body, influencing sleep-wake cycles, hormone release, and other physiological processes.
Histamine Release
The process by which histamine is released from immune cells into the body, often in response to an allergic reaction, leading to symptoms like itching, swelling, and redness.
Sympathetic Nervous System
A part of the autonomic nervous system that activates the body's fight-or-flight response during stressful situations.
Chronic Obstructive Pulmonary Disease (COPD)
A progressive lung disease that makes it hard to breathe due to obstruction of airflow.
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