Why Does Tissue Damage Occurs in Acute Rejection After Organ

question 3

Multiple Choice

Why does tissue damage occurs in acute rejection after organ transplantation?

• A) Th1 cells release cytokines that activate infiltrating macrophages, and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue.
• B) Circulating immune complexes are deposited in the endothelial cells of transplanted tissue, where the complement cascade lyses tissue.
• C) Receptors on natural killer cells recognize antigens on the cell surface of transplanted tissue, which releases lysosomal enzymes that destroy tissue.
• D) Antibodies coat the surface of transplanted tissue to which mast cells bind and liberate preformed chemical mediators that destroy tissue.

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Definitions:

Pigment

A substance that imparts color to other materials by absorbing a spectrum of light and reflecting certain wavelengths.

Dermatitis

Inflammation of the skin characterized by redness, itching, and often blistering.

Eczema

A condition that causes inflamed, itchy, cracked, and rough skin.

Melanosomes

Organelles within cells responsible for the synthesis, storage, and transport of melanin, the pigment in skin and hair.