Azidothymidine (AZT) Is a Reverse Transcriptase Inhibitor That Was Part

question 47

Multiple Choice

Azidothymidine (AZT) is a reverse transcriptase inhibitor that was part of the first class of antiviral drugs developed to treat HIV infection. Which of the following correctly describes how these drugs inhibited HIV infection?

• A) The drugs targeted and destroyed the viral genome before it could be reverse transcribed into DNA.
• B) The drugs bonded to the viral dsDNA and prevented it from being able to be used as a template for replication.
• C) The drug bonded to the viral reverse transcriptase enzyme and prevented it from making a DNA copy of viral RNA.
• D) The drugs prevented host cells from producing the enzymes used by the virus to replicate its genome.

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Definitions:

Regression

A statistical method used to determine the relationship between two or more variables, where one or more independent variables are used to predict the outcome of a dependent variable.

Analysis of Variance

A statistical procedure used to compare the means of three or more samples to determine if at least one of the sample means is significantly different from the others.

Null Hypothesis

A default hypothesis that there is no significant difference or effect, used as a starting point for statistical testing.

Test Statistic Value

A value derived from sample data during a hypothesis test, used to determine whether to reject the null hypothesis within the context of the test.