Unequal Crossing Over During Prophase I Can Result in One

question 43

Multiple Choice

Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. Hemoglobin Lepore is a form of hemoglobin that is missing a series of amino acids. If this form was caused by unequal crossing over, which of the following is the most likely consequence?

• A) There should also be individuals whose hemoglobin contains a tandem repeat of the amino acid sequence that was deleted in hemoglobin Lepore.
• B) Each of the genes in the hemoglobin gene family must show the same deletion.
• C) The gene with the deletion must have undergone exon shuffling.
• D) The deleted region must be located in a different area of the individual's genome.

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