The Abnormal Cleavage of Mannose Residues During the Posttranslational Processing

question 7

Multiple Choice

The abnormal cleavage of mannose residues during the posttranslational processing of glycoproteins has been shown to result in the development of a lupus-like autoimmune disease in mice. The abnormal cleavage is due to a mutation of the enzyme -mannosidase II. Based on your understanding of the processing of membrane proteins, you would predict this enzyme to be localized to which of the following?

• A)Nucleus
• B)Cytosol
• C)Golgi apparatus
• D)Lysosomes
• E)Peroxisomes

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Definitions:

Social Validity

The degree to which the goals, procedures, and outcomes of an intervention are acceptable and relevant to the participants and their community.

Non-disturbed Samples

Samples collected from natural or unchanged settings or populations, maintaining their original conditions without human-induced alteration or manipulation.

Face Validity

The extent to which a test appears to measure what it's supposed to measure, based on subjective judgment.

Content Validity

When the content of a test includes a representative sample of behaviours thought to be related to the construct (that is, the concept or entity) the test is designed to measure.