A Mutation in the Cdc28 Gene in the Budding Yeast

question 19

Multiple Choice

A mutation in the cdc28 gene in the budding yeast Saccharomyces cerevisiae causes cell-cycle arrest, giving rise to unbudded cells that look like "dumbbells." Treatment of wild-type cells with nocodazole, a drug that destabilizes some cytoskeletal polymers, leads to a similar phenotype. Based only on these observations, which statement is true regarding cdc28?

• A) cdc28 codes for a master regulatory kinase that phosphorylates other proteins.
• B) Nocodazole binds to the protein coded by the cdc28 gene.
• C) The product of the cdc28 gene is responsible for resistance to nocodazole.
• D) The product of the cdc28 gene is involved in cell cycle regulation.
• E) The product of cdc28 destabilizes the same cytoskeletal polymers that nocodazole also destabilizes.

Explain the significance of BATNA in negotiations and its role in determining negotiation outcomes.

Identify strategies for managing and overcoming resistance to change in organizational settings.

Understand the process of negotiation including the development of alternative deal packages and finding common ground.

Recognize the characteristics and implications of different types of changes as outlined in the Nadler-Tushman model.

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Definitions:

Class

In object-oriented programming, a template for creating objects, providing initial values for state (member variables) and implementations of behavior (member functions or methods).

Accessed

Refers to the action of retrieving or modifying the data stored in variables or data structures in a program.

Polymorphism

A programming concept allowing objects of different classes to be treated as objects of a common superclass, enabling methods to act differently based on the actual class of the object they are acting upon.

Retesting

The process of testing software again to confirm that fixes for defects are working and have not introduced new defects.