A Viral Version of the Src Kinase Called V-Src Is

question 35

Multiple Choice

A viral version of the Src kinase called v-Src is found in some retroviruses. Unlike the cellular Src, the v-Src kinase is constitutively active, and can drive the cell into uncontrolled growth and tumor formation. Which of the following molecular differences between the two versions of Src is more likely to be responsible for this?

• A) v-Src lacks the active-site tyrosine residue.
• B) v-Src lacks a lobe of the kinase domain.
• C) v-Src has multiple inhibitory tyrosine phosphorylation sites in the kinase domain.
• D) v-Src lacks the C-terminal tail that can bind to Src's SH2 domain.
• E) v-Src has a longer C-terminal tail.

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Definitions:

Power

The ability of a statistical test to detect an effect if the effect actually exists.

Type II Error

The error that occurs when failing to reject a false null hypothesis, also known as a false negative.

Type I Error

occurs when a true null hypothesis is incorrectly rejected in a statistical test.

Test Power

The probability that a statistical test will correctly reject the null hypothesis when it is false, indicating a test's effectiveness.