At the Replication Fork, the Template for the Lagging Strand

question 28

Multiple Choice

At the replication fork, the template for the lagging strand is thought to loop around. This looping would allow the lagging-strand polymerase to move along with the rest of the replication fork instead of in the opposite direction. The single-strand part of the loop is bound by the single-strand DNA-binding (SSB) proteins. As each Okazaki fragment is synthesized toward completion, how does the size of the loop change? What about the size of the SSB-bound part of the loop?

• A) Increases; increases.
• B) Increases; decreases.
• C) Decreases; increases.
• D) Decreases; decreases.
• E) Decreases; does not change.

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