In a Gene That Normally Contains Three Exons, Which of the Following

question 15

Multiple Choice

In a gene that normally contains three exons, which of the following changes probably will NOT activate the nonsense-mediated mRNA decay pathway? The sizes of exons 1 to 3 are 100, 150, and 200 nucleotide pairs, respectively.

• A) A nonsense mutation in exon 1.
• B) A nonsense mutation in exon 2.
• C) A mutation in the first intron resulting in the inclusion of a large intronic fragment in the mature mRNA.
• D) A frameshift mutation in exon 1.
• E) A mutation in exon 2 leading to its loss through exon skipping.

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A process in which a patient receives full disclosure of and understands the risks, benefits, and alternatives of a proposed procedure or treatment before agreeing to it.

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A sample taken for medical testing or research.

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