Consider the Two Feed-Forward Loops Below Containing Three Transcription Regulators

question 50

Short Answer

Consider the two feed-forward loops below containing three transcription regulators A, B, and C, where A receives the input signal and C generates the output. In the so-called coherent loop (left), A activates C both directly and indirectly, whereas in an incoherent loop (right), A activates C via one route and inactivates it via the other. Answer the following question(s) based on these network motifs.

-Considering the two particular feed-forward designs shown, would you expect the coherent (C) or the incoherent (I) loop to have a stable output and respond best to input signals that are above a certain threshold? Write down C or I as your answer.

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Definitions:

Conversion Disorder

A mental condition in which a person experiences neurological symptoms, such as paralysis or blindness, that cannot be explained by medical evaluation.

Dissociative Disorders

Mental disorders that involve disruptions or breakdowns of memory, awareness, identity, or perception.

DSM

Diagnostic and Statistical Manual of Mental Disorders, a comprehensive classification of officially recognized psychiatric disorders, used by mental health professionals to diagnose and categorize mental conditions.

Dissociative Amnesia

A psychological condition where a person experiences memory loss that cannot be attributed to normal forgetfulness.