When Unfolded Proteins Accumulate in the Lumen of the Endoplasmic

question 48

Short Answer

When unfolded proteins accumulate in the lumen of the endoplasmic reticulum due to inefficient folding conditions, a membrane-bound protein kinase is activated and phosphorylates a subunit of the translation initiation factor eIF2. Indicate which of the following events would (Y) or would not (N) occur as a result. Your answer would be a four-letter string composed of letters Y and N only, e.g. YYYY.
( ) eIF2 binds tightly to the ribosome.
( ) Translation initiation is stimulated.
( ) The GDP-bound form of eIF2 accumulates.
( ) eIF2B is activated.

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