You Have Devised Genetic Screens to Identify Gain- and Loss-Of-Function

question 78

Short Answer

You have devised genetic screens to identify gain- and loss-of-function mutations in the Escherichia coli DNA ligase gene. One of the screens (1) seeks mutant cells that are infected more readily with a ligase-deficient strain of T4 phage. The other screen (2) seeks mutant cells that have increased radiation sensitivity at high temperatures. Indicate whether each of the following descriptions better applies to screen 1 (1) or screen 2 (2). Your answer would be a three-digit number composed of digits 1 and 2 only, e.g. 122.
( ) It would identify gain-of-function DNA ligase mutants.
( ) It would identify loss-of-function DNA ligase mutants.
( ) It would identify conditional mutants.

---

Definitions:

Signs

Symbols or objects that convey meaning beyond their immediate, literal sense, often used in communication.

Symbol Systems

Complex sets of symbols and meanings that are used by societies to communicate, interpret, and understand the world around them.

Linguistics

The scientific study of language and its structure, including the study of morphology, syntax, phonetics, and semantics.

Postmodern Theory

A theory that distrusts grand narratives and ideologies, focusing on the relativistic nature of truth and emphasizing the role of language, power relations, and cultural norms.