Some Feed-Forward Motifs Are Capable of Generating a Brief Pulse

question 91

Multiple Choice

Some feed-forward motifs are capable of generating a brief pulse of gene activation in response to a sustained input signal: in such motifs, the signal activates an activator (A) and a repressor (R) , both of which control the expression of the same gene. The quantitative output of the gene depends in part on the relative affinities of A and R for binding to the cis-regulatory sequences of the target gene. Under which of the following conditions is a brief pulse of gene activation observed in response to a sustained input signal? KA and KR are the association constants for A and R, respectively.

• A) KA = KR
• B) KA << KR
• C) KA >> KR
• D) KAKR > 1

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