The nicotinic acetylcholine receptor is a cation channel in the plasma membrane of some neurons. It is composed of five subunits, each of which is a transmembrane protein. The hydropathy plot for each mature subunit is qualitatively represented in the following diagram. How many membrane-spanning alpha helices do you expect to exist in each subunit?
Definitions:
Insertions
The addition of one or more nucleotide pairs into a genetic sequence, which can lead to changes in gene function or regulation.
Phenotype
The set of observable characteristics or traits of an organism, resulting from the interaction of its genetic makeup with the environment.
Protein-Coding Sequence
A segment of DNA or RNA that is translated into a protein, containing instructions for the amino acid sequence of the protein.
Gene Expression
The process by which information from a gene is used to synthesize a functional gene product, often a protein, which can affect a cell's structure and function.
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