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Rough microsomes can be subjected to a "salt extraction" procedure in which a high salt concentration is used to remove membrane-associated ribosomes and peripheral proteins. Such salt-extracted microsomes are known to be translocation-incompetent, meaning that when present co-translationally in vitro, they fail to protect translated proteins from protease digestion. However, adding back an 11S particle (S is the sedimentation coefficient) purified from the salt-wash fraction is sufficient to restore the protein-translocation activity of the salt-extracted microsomes. Which of the following do you think is true regarding the 11S particle?
Fixed Costs
Costs that do not vary with the level of production or sales, such as rent, salaries, and insurance premiums, providing stability to a company's expense structure.
Depreciation Expense
The allocated amount of the cost of an asset that is written off as an expense over its useful life.
Sales Price
The sum of money that a purchaser spends to acquire a product or service from a vendor.
Contribution Margin
The revenue remaining after deducting variable costs, which can be used to cover fixed costs and contribute to profit.
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