If This Protein Is Unable to Hydrolyze Its Bound GTP

question 17

Multiple Choice

If this protein is unable to hydrolyze its bound GTP, invaginated clathrin-coated pits accumulate but fail to pinch off from the plasma membrane. In neurons, long vesicle necks collared by the protein are observed and presynaptic endocytosis is blocked. This protein …

• A) contains a PI(4,5)P₂ binding domain and a GTPase domain.
• B) recruits other proteins to the neck of the vesicle.
• C) may change the membrane lipid composition by recruiting lipid-modifying enzymes.
• D) may directly distort the membrane using the energy from GTP hydrolysis.
• E) All of the above.

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