Whereas the Cholera Toxin ADP-Ribosylates the α Subunit of Stimulatory

question 16

Multiple Choice

Whereas the cholera toxin ADP-ribosylates the α subunit of stimulatory G protein (Gs) , thereby blocking GTP hydrolysis, pertussis toxin ADP-ribosylates the α subunit of inhibitory G protein (Gᵢ) and prevents interaction with the receptor. What is the effect of these toxins on the concentration of intracellular cAMP?

• A) Cholera toxin tends to increase cAMP concentration, whereas pertussis toxin tends to decrease cAMP concentration.
• B) Cholera toxin tends to decrease cAMP concentration, whereas pertussis toxin tends to increase cAMP concentration.
• C) They both tend to increase cAMP concentration.
• D) They both tend to decrease cAMP concentration.

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