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Whereas the Cholera Toxin ADP-Ribosylates the α Subunit of Stimulatory

question 16

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Whereas the cholera toxin ADP-ribosylates the α subunit of stimulatory G protein (Gs) , thereby blocking GTP hydrolysis, pertussis toxin ADP-ribosylates the α subunit of inhibitory G protein (Gᵢ) and prevents interaction with the receptor. What is the effect of these toxins on the concentration of intracellular cAMP?


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