How Does the Expression of Delta on the Surface of a Cell

question 44

Multiple Choice

How does the expression of Delta on the surface of a cell activate the expression of certain genes in the nucleus of its neighboring cell?

• A) Delta binding activates Notch, which activates a transcriptional activator through the JAK-STAT pathway.
• B) Delta binding leads to the stabilization of a cytoskeleton-associated transcriptional activator.
• C) Delta binding releases the intracellular tail of Notch, which enters the nucleus and converts a transcriptional repressor into a transcriptional activator.
• D) Delta binding leads to Notch-mediated recruitment of protein complexes to the plasma membrane, resulting in the degradation of a transcriptional repressor.
• E) Delta binding leads to the proteolytic cleavage of Notch and inhibition of its activity as a transcriptional repressor, leading to the activation of target genes.

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