How Is the Activation of Epidermal Growth Factor Receptor (EGFR)

question 28

Multiple Choice

How is the activation of epidermal growth factor receptor (EGFR) different from that of insulin receptor (IR) ?

• A) EGFR is a dimer in its inactive and active forms, whereas IR dimerizes only when active.
• B) EGFR activation requires dimerization, whereas IR can become activated as a monomer.
• C) EGFR is activated by transautophosphorylation, whereas IR activation is phosphorylation-independent and is a simple consequence of receptor dimerization.
• D) Unlike IR activation, EGFR activation involves an asymmetric arrangement of the intracellular kinase domains.
• E) Both C and D above.

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