Dynamitin Is a Subunit of the Dynactin Complex

question 18

Multiple Choice

Dynamitin is a subunit of the dynactin complex. Its overexpression leads to the disassembly of the complex, and it is therefore considered a dynactin inhibitor. Which of the following processes would happen if dynamitin is overexpressed in a cell?

• A) The motile cilia (if any) would stop beating because the axonemal dyneins could not attach to their neighboring microtubules.
• B) The Golgi apparatus would fragment and become dispersed because the cytoplasmic dyneins could not associate with the Golgi membranes.
• C) The endoplasmic reticulum would collapse because it could not recruit enough kinesins.
• D) The nuclear envelope would disintegrate because the nuclear lamins could not interact with the cytoplasmic cytoskeleton.
• E) The cortex would lose its integrity because the Arp 2/3 complex would also be inhibited.

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Definitions:

Representative Heuristic

A mental shortcut used in decision-making, where the likelihood of an event is estimated based on how similar it is to the stereotype of the event.

Correspondent Inference

The process by which observers infer the stable dispositions of others from their observed behavior, particularly when the actions are non-common or unexpected.

Representativeness Heuristic

The tendency to overestimate the likelihood that a target is part of a category if the person has features that seem representative of that category.

Availability Heuristic

A mental shortcut that relies on immediate examples that come to a person's mind when evaluating a specific topic, concept, method, or decision.