Platelets That Express a Constitutively Active Rap1 Are Able to Activate

question 48

Short Answer

Platelets that express a constitutively active Rap1 are able to activate integrins even in the absence of thrombin stimulation. In contrast, cells expressing a binding-deficient version of talin are unable to perform integrin activation. In platelets expressing both of these mutant proteins, what would you expect to observe: the Rap1 gain-of-function phenotype (R) or the talin loss-of-function phenotype (T), as described above? Write down R or T as your answer.

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Definitions:

Debt

Money owed by one party to another under the condition that it will be paid back, often with interest.

Statute Law

Written laws enacted by a legislative body, governing various aspects of societal conduct.

Lesser Sum

Refers to an amount of money that is smaller in comparison to another figure or expectation.

Obliged

Required or bound legally or morally to do something.