How Does Talin Activate the Inside-Out Signaling Through Integrin

question 38

Multiple Choice

How does talin activate the inside-out signaling through integrin?

• A) It binds to both integrin subunits to bring them together in an interlocked conformation.
• B) It is a protein kinase that phosphorylates both integrin subunits and induces activation by conformational change.
• C) It competes with the α subunit for binding to the β subunit, therefore blocking intimate α-β linkage.
• D) It binds to the α subunit, and dissociates the dimer into individual subunits that are functionally active.

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