Platelets That Express a Constitutively Active Rap1 Are Able to Activate

question 48

Short Answer

Platelets that express a constitutively active Rap1 are able to activate integrins even in the absence of thrombin stimulation. In contrast, cells expressing a binding-deficient version of talin are unable to perform integrin activation. In platelets expressing both of these mutant proteins, what would you expect to observe: the Rap1 gain-of-function phenotype (R) or the talin loss-of-function phenotype (T), as described above? Write down R or T as your answer.

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