The Effect of the Deletion of One Copy of the Gene

question 5

Multiple Choice

The effect of the deletion of one copy of the gene encoding p53 is different from the effects caused by other p53 mutations. For example, some loss-of-function mutations in the DNA-binding domain of p53 cripple its function as a transcription regulator. Such a mutation in only one copy of the p53 gene can be enough to confer a p53 loss-of-function phenotype, even when the other copy of the gene on the homologous chromosome is wild type. This is because …

• A) p53 is a proto-oncogene.
• B) these mutations are recessive.
• C) p53 is a tumor suppressor.
• D) p53 forms a tetramer.
• E) p53 can induce apoptosis.

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Definitions:

Theories of Consumption

Refers to various frameworks for understanding how and why individuals or societies engage in buying, using, and disposing of goods and services.

Marxist Tradition

A body of thought derived from the works of Karl Marx, focusing on the role of class struggle in societal change and development.

Institute of Social Research

A research organization affiliated with a university, focusing on the analysis and understanding of social structures and processes.

Frankfurt School

A group of mid-20th century thinkers who combined Marxist critical theory with psychoanalysis to analyze the cultural and societal changes in capitalist societies.