The Gene Encoding Hes7 in Mouse Contains Three Introns

question 6

Multiple Choice

The gene encoding Hes7 in mouse contains three introns. Any or all of these introns can be deleted to alter the delay associated with transcription and splicing of Hes7 mRNA. As a result of such deletions, either the oscillation frequency of this gene's expression can change (result 1) or the oscillatory behavior can disappear altogether (result 2) . One of these two results is obtained when only one intron is deleted from the gene, while the other result is obtained when all three introns are removed. Would you expect the oscillation frequency to increase or decrease if result 1 is obtained? Which result (1 or 2) would you expect to observe when all three introns are deleted?

• A) Increase; result 1
• B) Increase; result 2
• C) Decrease; result 1
• D) Decrease; result 2

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Definitions:

Males Affected

Refers to phenomena, conditions, or studies specifically concerning or impacting male individuals.

Phenylketonuria

A genetic disorder characterized by an inability to metabolize the amino acid phenylalanine, leading to potential brain damage if untreated.

Amino Acid

Organic compounds that serve as the building blocks of proteins, necessary for various bodily functions and processes.

Chromosome Disorder

A genetic condition caused by abnormalities in the number or structure of chromosomes, often leading to developmental issues or health problems.