Considering the Role of Notch and Wnt Signaling Pathways in Epithelial

question 9

Short Answer

Considering the role of Notch and Wnt signaling pathways in epithelial cell differentiation in the mammalian intestine, indicate whether each of the following changes in "minigut" organoids in culture is expected to lead to a higher (H) or lower (L) number of stem cells. Your answer would be a two-letter string composed of letters H and L only, e.g. HH.
( ) RNA interference knockdown of Hes1, an essential downstream effector of the Notch signaling pathway
( ) Deletion of the gene encoding Apc, a gene that is mutated in many colorectal cancers

Learn how to use guidance tests and informational interviews for career planning.

Recognize the value and methods of professional networking in job searching.

Identify industry trends and their impact on employment opportunities.

Comprehend the steps of the career planning and advancement process.

---

Definitions:

Economic Conditions

The overall state of a country or region's economy, characterized by factors like GDP growth, unemployment rate, and inflation.

Initial Recognition

The first accounting entry for an asset or liability, marking its introduction in the financial statements at its fair value.

Financier Lessor

An entity engaged in the business of leasing out assets, typically providing the finance to purchase the asset which is then leased to the user.

Lease Receivable

An asset representing the right to receive future lease payments from lessees under lease agreements, reflecting the value of the asset leased out.