Consider the Following Three Diseases Associated with Activation-Induced Deaminase (AID)

question 13

Short Answer

Consider the following three diseases associated with activation-induced deaminase (AID) and indicate whether you think each of them is accompanied by a higher (H) or lower (L) AID activity in the affected cells compared to normal cells. Your answer would be a three-letter string composed of letters H and L only, e.g. LLL.
( ) Burkitt's lymphoma is a cancer of B lymphocytes originating from the germinal center. In this cancer, chromosomal translocations are observed between the immunoglobulin heavy-chain genes and proto-oncogenes (genes whose overexpression can promote cancer), resulting in aberrant expression of the latter.
( ) Diffuse large B cell lymphoma is a cancer of B lymphocytes in which, in addition to chromosomal translocations, high mutation rates are observed in many genes including proto-oncogenes.
( ) Hyper IgM syndrome is a genetic immunodeficiency syndrome in which IgM antibodies are produced by B cells at high levels and for extended periods, while levels of IgA, IgE, and IgG antibodies are abnormally reduced.

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Definitions:

Posterior To The Liver

Located behind the liver, referring to the spatial relationship of organs or structures within the body.

Posterior To The Stomach

Located behind the stomach, referring to anatomical structures that are situated toward the back of the human body in relation to the stomach.

Left Side Of The Abdomen

The left portion of the abdomen, housing important organs such as part of the stomach, the left kidney, the spleen, and portions of the colon.

Cisterna Chyli

A dilated sac at the lower end of the thoracic duct into which lymph from the intestinal trunk and two lumbar lymphatic trunks flow.