In a Systematic Review of Aspirin as a Possible Preventive

question 8

Multiple Choice

In a systematic review of aspirin as a possible preventive of lung cancer (Feskanich et al., British Journal of Cancer, 2007
Http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360462/pdf/6603996a.pdf) , the
Authors identified all papers with original data that assessed the relation between
Aspirin use and lung cancer incidence or mortality (N=18) and then excluded:
- Retrospective analyses (N=4)
- Prospective studies that did not account for smoking (N=3)
- Studies with no quantitative measure of aspirin use (N=2) .
Which of the following statements are true? (select all that apply)

• A)The results of the review will be biased because 9 of the 18 studies were excluded
• B)It is appropriate to exclude retrospective studies because of potential biases in aspirin recall and selection of controls
• C)It is appropriate to exclude retrospective studies because their results are likely to be confounded
• D)It is inappropriate to exclude the retrospective studies because there is only a small number of studies overall
• E)It is appropriate to exclude studies with no control for confounding by smoking because this is likely to influence the association between aspirin and lung cancer

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Definitions:

Original Investment

The initial amount of money put into a project, asset, or venture.

Sales And Leaseback Arrangement

A financial transaction where one sells an asset and leases it back for the long-term; thus, one continues to use the asset but no longer owns it.

Operating Lease

A lease agreement allowing the use of an asset without ownership, typically with shorter terms than a finance lease.

Asset-Based Loan

An asset-based loan is a type of lending, often secured by a company's assets, where the loan amount is based on a percentage of the value of those assets.