Exhibit 6A This Is a Reaction Going on in Your

question 26

Multiple Choice

Exhibit 6A This is a reaction going on in your muscle cells right this very minute: The enzyme triose phosphate isomerase catalyzes this reaction in the forward direction as part of the glycolytic pathway. It follows simple Michaelis-Menten kinetics:
Typical cellular concentrations: triose phosphate isomerase = 0.1 nM
Dihydroxyacetone phosphate = 5 µM glyceraldehyde-3-phosphate = 2 µM
Refer to Exhibit 6A. "Restrainin" is an inhibitor of triose phosphate isomerase. When it is added to cells at a concentration of 0.4 nM, the enzyme's apparent K_M for the substrate is altered to 100 µM, but the V_max is unchanged.
In the following graph, which line best represents the Lineweaver-Burk plot obtained in the presence of restrainin?

• A) A
• B) B
• C) C
• D) D
• E) E

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