Patients with Parkinson's Disease Are Treated with L-DOPA, a Hydrophobic

question 62

Multiple Choice

Patients with Parkinson's disease are treated with L-DOPA, a hydrophobic precursor to dopamine, a hydrophilic neurotransmitter that is depleted in these patients. What is the most probable reason why these patients are given the precursor L-DOPA instead of dopamine?

• A) L-DOPA is better at activating dopamine receptors than dopamine.
• B) L-DOPA is more toxic than dopamine.
• C) L-DOPA cannot cross the blood-brain barrier.
• D) Dopamine cannot cross the blood-brain barrier.
• E) Dopamine given orally could activate acetylcholine receptors.

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