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Read the paragraph below and answer the questions that follow by selecting the letter of the correct response.
When Lewis and Clark made their way through what is now North Dakota, the Shoshone Indian woman named Sacajawea joined the team of explorers. Because the expedition was traveling with a Native American, other tribes did not attack the group. In fact, one tribe even supplied horses to help the explorers and their interpreter cross the Rocky Mountains. This invaluable team member taught the men how to find medicine and food in the wilderness and once even saved the records of the journey when a canoe overturned during a storm. She reached the Pacific Ocean with Lewis and Clark in 1805. Her fame eventually spread; one of the best-known monuments to her is a statue in Portland, Oregon.
Which of the following is a pronoun used to refer to the subject of the paragraph?
Endorphin Agonists
These are substances that mimic the action of endorphins, neurotransmitters in the brain that reduce pain and induce feelings of pleasure.
Endorphin Antagonists
Substances that block the action of endorphins, natural pain-relieving compounds in the body, often used in research to understand pain pathways.
Immediate Pain
The experience of pain that occurs directly following an injury or other harmful stimulus.
Opiate Drug
A category of drugs derived from opium, used for their pain-relieving properties, but also known for their high potential for addiction and abuse.
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