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A 28-Year-Old Man Comes to the Office Due to Persistent

question 86

Multiple Choice

A 28-year-old man comes to the office due to persistent fatigue. For the past several weeks, he has been having trouble sleeping and is frequently late for work as he has difficulty getting out of bed. At work, his mind wanders, and his supervisor has commented that the quality of his work has deteriorated. The patient says, "I've been feeling down and don't feel like doing anything. My appetite is poor. I no longer go out with my friends and haven't gone to the gym in weeks." The patient has no significant medical or psychiatric history. He has 1 or 2 alcoholic drinks several days a week but does not use illicit drugs. Routine laboratory evaluation, including thyroid function tests and serum B₁₂ level, is normal. Physical examination is unremarkable. Mental status examination shows a cooperative man with sad affect. No delusions are elicited. The patient says he sometimes wishes he could "go to sleep and not wake up," but has no suicidal intent or plan. First-line pharmacotherapy for this patient most likely involves a drug with which of the following mechanisms of action?

Definitions:

Grade

An evaluation or ranking, often numerical or alphabetical, used to represent the quality or performance level of an academic achievement or product.

Spearman's Rank Correlation

A measure that does not rely on parameters, used to determine the correlation in ranking, and assesses the ability to explain the relationship between two variables with a monotonic function.

Wheat Yield

The amount of wheat produced per unit area, commonly measured in bushels per acre or kilograms per hectare.

Rainfall

The total amount of rain that falls in a specific area over a specific period, often measured in millimeters or inches.