A 14-Year-Old Boy Is Brought to the Emergency Department After

question 75

Multiple Choice

A 14-year-old boy is brought to the emergency department after accidental ingestion of a chicken bone that lodged in his esophagus.  Upper endoscopy is performed and the bone is successfully removed.  However, the patient is incidentally found to have mild hypercalcemia on laboratory testing.  On follow-up with his primary care provider 2 weeks later, he has no symptoms and clinical examination is unremarkable.  Further questioning reveals that several of his family members also have mild hypercalcemia.  Subsequent laboratory studies show a borderline high parathyroid hormone concentration, very low urinary calcium level, and normal 25-hydroxyvitamin D level.  A mutation in which of the following receptors is most likely responsible for this patient's laboratory abnormalities?

• A)Intracellular receptor with a DNA-binding domain
• B)Membrane-bound receptor coupled with a G protein
• C)Transmembrane ligand-gated ion channel
• D)Transmembrane receptor associated with intrinsic tyrosine kinase activity
• E)Transmembrane receptor causing activation of Janus kinase/STAT pathway

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Definitions:

Smaller Buckets

A term used in project management and process optimization, referring to breaking down tasks or storage needs into smaller, more manageable units.

Lot-For-Lot Ordering

A inventory management strategy where exactly the quantity needed for production or demand is ordered, minimizing the inventory holding costs.

MRP Plan

Material Requirements Planning; a system for calculating materials and scheduling production to meet demand.

Gross Requirements

The total demand for an item, inclusive of direct and indirect requirements, before any adjustments for on-hand inventory or scheduled receipts.