A 34-Year-Old Woman Comes to the Office After Her Sister

question 144

Multiple Choice

A 34-year-old woman comes to the office after her sister was diagnosed with breast cancer.  She has no nipple discharge, breast lumps, or discomfort.  Breast examination is normal.  Her sister was found to have a multiple base pair insertion affecting exon 11 of the BRCA1 gene that leads to a frameshift mutation.  A screening test to evaluate for a similar insertion mutation in the patient's BRCA1 gene is performed.  The test uses polymerase chain reaction (PCR) to amplify the target exon and gel electrophoresis to assess the size of the exon compared to the wild-type allele.  Which of the following must be known in order to perform the amplification part of this analysis?

• A)Restriction enzyme susceptibility sites within the target exon
• B)The amino acid sequence of the abnormal BRCA1 protein
• C)The cDNA nucleotide sequence
• D)The complete nucleotide sequence of the target exon
• E)The nucleotide sequence of the regions flanking the target exon

Recognize the philosophical and operational differences between judicial activism and judicial restraint.

Describe the structure and functions of the U.S. Supreme Court, including decision-making processes and the types of opinions issued.

Understand the concept and implications of a writ of certiorari.

Articulate the significance of senatorial courtesy and its impact on judicial appointments.